Side Effects, Interaction and Dosing of Vitamin C
Side Effects, Interaction and Dosing of Vitamin C are discussed below:
Vitamin C is likely safe for most people when taken in recommended doses appropriately. It can be by mouth, applied to the skin, injected into the muscle, and injected intravenously (by IV).
Vitamin C might cause nausea, vomiting, heartburn, stomach cramps, headache, and other side effects in some people. The chance of getting these side effects increases the more vitamin C intake. Amounts higher than 2000 mg daily are unsafe and may cause a lot of side effects, including kidney stones and severe diarrhea. Amounts greater than 1000 mg daily greatly increase the risk of kidney stone recurrence in people who have had a kidney stone.
Special precautions should be taken for the below cases:
Vitamin C is likely safe for pregnant or breast-feeding women when taken by mouth in recommended dose or when given intravenously (by IV) or intramuscularly and appropriately. The recommended dose is not greater than 2000 mg daily for women over 19 years-old, and 1800 mg daily for women 14 to 18 years-old. Taking too much vitamin C during pregnancy can cause problems for the newborn baby. Vitamin C is unsafe when taken by mouth in excessive amounts.
Vitamin C is likely safe when taken by mouth appropriately. Vitamin C is unsafe when taken more than the recommended dose orally. The amount should not be higher than 400 mg daily for children 1 to 3 years, 650 mg daily for children 4 to 8 years, 1200 mg daily for children 9 to 13 years, and 1800 mg daily for adolescents 14 to 18 years.
Alcohol intake can cause the body to excrete vitamin C in the urine. People who regularly use alcohol, especially those who have other illnesses, often have vitamin C deficiency. These people might need to be treated for a longer time than normal to restore vitamin C levels to normal.
Taking vitamin C along with vitamin E and alpha-lipoic acid might worsen mental function in people with Alzheimer's disease.
Avoid taking supplements containing vitamin C or other antioxidant vitamins (beta-carotene, vitamin E) immediately before and following angioplasty without the supervision of a health care professional. These vitamins seem to interfere with proper healing.
Weight loss surgery can cause the body to absorb more oxalate from food. This can increase the amount of oxalate in the urine. Too much oxalate in the urine can cause problems such as kidney stones. Vitamin C can also increase the amount of oxalate in the urine. Taking large amounts vitamin C after weight loss surgery might increase the risk of having too much oxalate in the urine.
Cancerous cells collect high concentrations of vitamin C. It is advisable to use high doses of vitamin C under the supervision of your oncologist.
Vitamin C can increase the amount of oxalate in the urine. Too much oxalate in the urine can increase the risk of kidney failure in people with kidney disease.
Vitamin C might raise blood sugar. If Vitamin C taken in amounts greater than 300 mg per day may increases the risk of death from heart disease in older women with diabetes. Do not take vitamin C in doses greater than those found in basic multivitamins.
Large amounts of vitamin C can cause red blood cells to break in people with this condition. It is a metabolic deficiency. Avoid excessive amounts of vitamin C.
Large amounts of vitamin C can increase the chance of getting kidney stones. Do not take vitamin C in amounts greater than those found in basic multivitamins.
Vitamin C levels are reduced during a heart attack. However, low vitamin C has not been linked to an increased risk for heart attack.
Long-term use of vitamin C in high doses before a kidney transplant may increase the risk of transplant rejection or delay how long it takes until the transplanted kidney works.
Taking vitamin C along with vitamin E might worsen psychosis in some people with schizophrenia when taken with antipsychotic drugs.
Smoking and chewing tobacco lowers vitamin C levels. Vitamin C intake in the diet should be increased in people who smoke or chew tobacco.
The body breaks down estrogens to get rid of them. Vitamin C might decrease the rate of breakdown of estrogens. Taking vitamin C along with estrogens might increase the effects and side effects of estrogens.
Large amounts of vitamin C might decrease how much fluphenazine (Prolixin) is in the body. Taking vitamin C along with fluphenazine (Prolixin) might decrease the effectiveness of fluphenazine (Prolixin).
Vitamin C is an antioxidant. There is some concern that antioxidants might decrease the effectiveness of some medications used for cancers. But it is too soon to know if this interaction occurs.
Taking large doses of vitamin C might reduce how much of some medications used for HIV/AIDS stays in the body. This could decrease the effectiveness of some medications used for HIV/AIDS.<br /> Some of these medications used for HIV/AIDS include amprenavir (Agenerase), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Fortovase, Invirase).
Taking vitamin C, beta-carotene, selenium, and vitamin E together might decrease the effectiveness of some medications used for lowering cholesterol. It is not known if vitamin C alone decreases the effectiveness of some medications used for lowering cholesterol. Some medications used for lowering cholesterol include atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), and pravastatin (Pravachol).
Taking vitamin C along with vitamin E, beta-carotene, and selenium might decrease some of the beneficial effects of niacin. Niacin can increase the good cholesterol. Taking vitamin C along with these other vitamins might decrease the effectiveness of niacin for increasing good cholesterol.
Warfarin (Coumadin) is used to slow blood clotting. Large amounts of vitamin C might decrease the effectiveness of warfarin (Coumadin). Decreasing the effectiveness of warfarin (Coumadin) might increase the risk of clotting. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.
Be watchful with the below combination as there might be minor interaction:
The body breaks down acetaminophen (Tylenol, others) to get rid of it. Large amounts of vitamin C can decrease how quickly the body breaks down acetaminophen.
The body breaks down aspirin to get rid of it. Large amounts of vitamin C might decrease the breakdown of aspirin. Decreasing the breakdown of aspirin might increase the effects and side effects of aspirin. It is advisable not take large amounts of vitamin C if you take large amounts of aspirin.
Vitamin C might decrease the rate of breakdown of choline magnesium trisalicylate (Trilisate).
Vitamin C is taken up by cells. Taking nicardipine (Cardene) along with vitamin C might decrease the amount of absorption of vitamin C by cells.
Vitamin C is taken up by cells. Taking nifedipine (Adalat, Procardia) along with vitamin C might decrease the amount of absorption of vitamin C by cells.
The daily recommended dietary allowances (RDAs) are:
2 liters of solution containing polyethylene glycol and vitamin C is used the evening prior to colonoscopy or as a split-dose taken on the evening prior to and the morning of colonoscopy.
200 mg of vitamin C per 30 mg of iron.
500 mg of vitamin C, 400 IU of vitamin E, and 15 mg of beta-carotene, with or without 80 mg of zinc, per day for up to 10 years.
1-3 grams daily.
500 mg of vitamin C each day for 50 days starting right after the injury.
1250 mg of vitamin C with 680 IU of vitamin E per day for 4 weeks has been used.
1-2 grams of vitamin C per day for 1-3 days before heart surgery followed by 1-2 grams in two divided doses daily for 4-5 days after heart surgery has been used.
600 mg to 1 gram of vitamin C per day for 3-8 weeks before heavy exercise has been used.
1200 mg of vitamin C daily along with omeprazole has been used.
200-300 mg of vitamin C three times per week for 3-6 months has been used.
500 mg of vitamin C per day along with blood pressure-lowering medication has been used.
3-6 grams of vitamin C daily has been used.
1 gram of vitamin C in the form of calcium ascorbate daily for 2 weeks has been used.
2 grams of vitamin C along with 1000 IU vitamin E taken before sun exposure has been used.
500 mg vitamin C each day for at least 4 weeks.
A formulation containing 10% vitamin C, 2% zinc sulfate, and 0.5% tyrosine applied daily for 8 weeks can be used.
Most topical preparations used for aged or wrinkled skin are applied daily. Creams containing 3% to 10% vitamin C can be used. A specific vitamin C formulation (Cellex-C High Potency Serum) used 3 drops applied daily to areas of facial skin. Avoid applying vitamin C preparations to the eye or eyelids. Also avoid contact with hair or clothes. It can cause discoloration.
2 grams of vitamin C once or twice in the day before heart surgery followed by 1-2 grams daily for 4-5 days after heart surgery has been used.
The daily recommended dietary allowances (RDAs) are:
100 mg of vitamin C.
25-70 mg of vitamin C taken with iron-containing foods has been used.
70 mg of vitamin C per day for 2 months can be used in adolescent boys.
100 mg of vitamin C can be used.
100 mg of vitamin C has been used.